No personalized mRNA neoantigen vaccine trial or clinical vaccine result is present. The CML trial signal is TKI dose reduction/withdrawal, not vaccination (NCT04147533). The new mechanistic evidence identifies an HLA-A2-restricted BCR-ABL E255V neoepitope and E255V-specific engineered TCRs for adoptive T-cell therapy; it does not support an mRNA vaccine program (PMID:39931057; DOI:10.3389/fimmu.2025.1518691). No vaccine lead opened. ```json { "leads": [], "candidates": [], "dossiers": [], "retired": [], "ledger_moves": [], "next_queries": [ "\"chronic myeloid leukemia\" personalized mRNA neoantigen vaccine", "\"CML\" \"neoantigen vaccine\" mRNA", "\"BCR-ABL\" neoantigen mRNA vaccination" ], "summary_line": "No personalized mRNA vaccine signal; evidence supports TKI management and E255V-directed TCR therapy (NCT04147533; PMID:39931057)." } ```

**Citing claims properly** I need to ensure that every claim I make has a proper prose citation. There isn't actually a personalized mRNA neoantigen vaccine to reference, and the potential leads seem to point towards mutation-specific TCR rather than an mRNA vaccine. The user expects no vaccine signal, so I'll need to clarify that there isn’t any current study on personalized mRNA vaccines. Citations from both NCT and PMID will be essential in my summary! I should also consider how to format the JSON with empty candidates efficiently. **Ensuring clarity in claims** I need to clarify that there’s no personalized mRNA vaccine signal; the evident alternatives are TKI withdrawal and E255V TCR engineering (using NCT and PMID references). I must express that nothing has been killed in terms of existing leads, and I also need to ensure appropriate claims are cited. I can frame it as “No existing lead.” The JSON format is valid, but I should avoid using literal citation IDs. It’s important to highlight that there’s no vaccine signal due to evidence absence!